MassARRAY multigene screening combined with LDL-C and sdLDL-C detection for more favorable outcomes in type 2 diabetes mellitus therapy
نویسندگان
چکیده
Abstract Background To determine the clinical value of multigene polymorphisms, LDL-C and sdLDL-C on T2DM therapy. Methods In total, 352 patients before after treatment 48 healthy individuals were enrolled in this study. detected by Quantimetrix Lipoprint System. The 11 gene polymorphisms— HTR3B (rs2276307, A > G), APOE (rs7412, c.526C T), (rs429358, c.388 T C), CYP2C9*3 (rs1057910, c.1075A KIF6 (rs20455, c.2155 HMGCR (rs17238540, (rs17244841, ABCB1 (rs2032582, C/T), HTR7 (rs1935349, C SLCO1B1 (rs4149056, c.521 CETP (rs708272, G A)—were screened these Agena Bioscience MassARRAY system Results Genetic polymorphisms associated with statin effects pretreatment detected, then results showed that all genes had heterozygous mutation, 7 homozygous mutation patients, more specifically reflected common Chinese patients. treatment, sdLDL mainly existed higher mean levels than people. After pharmacotherapy, coincidence rates decreases 88.35% (311/352) 84.09% (296/352), consistent remission. Conclusions Gene related to pharmacotherapy And expression was disease course. Combined screening therapy detection could better assist treatment.
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ژورنال
عنوان ژورنال: BMC Medical Genomics
سال: 2021
ISSN: ['1755-8794']
DOI: https://doi.org/10.1186/s12920-021-00937-8